Source
pharmaphorum
Novo Nordisk is planning to move ahead with regulatory filings for etavopivat, potentially a first-in-class therapy for sickle cell disease, based on positive results in a phase 3 trial.
In the HIBISCUS trial, oral PKR activator etavopivat showed a 27% reduction in the annualised rate of vaso-occlusive crisis (VOC) events – the excruciatingly painful attacks that occur in SCD patients when red blood cells become misshapen and block blood vessels – compared to placebo when added to standard treatment.
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